21 CFR 556.344 - Ivermectin.

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§ 556.344 Ivermectin.

(a) Acceptable Daily Intake (ADI). The ADI for total residues of ivermectin is 5 micrograms per kilogram of body weight per day.

(b) Tolerances -

(1) Liver. A tolerance is established for 22,23-dihydroavermectin B1a (marker residue) in liver (target tissue) as follows:

(i) Cattle. 1.6 parts per million.

(ii) Swine. 20 parts per billion.

(iii) Sheep. 30 parts per billion.

(iv) Reindeer. 15 parts per billion.

(v) American bison. 15 parts per billion.

(2) Muscle. Muscle residues are not indicative of the safety of other edible tissues. A tolerance is established for 22,23-dihydroavermectin B1a (marker residue) in muscle as follows:

(i) Swine. 20 parts per billion.

(ii) Cattle. 650 parts per billion.

(c) Related conditions of use. See §§ 520.1192, 520.1195, 520.1197, 522.1192, 522.1193, 524.1193, and 558.300 of this chapter.

[63 FR 54352, Oct. 9, 1998, as amended at 64 FR 26671, May 17, 1999; 79 FR 64117, Oct. 28, 2014]

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United States Code

Title 21 published on 2015-04-01

The following are ALL rules, proposed rules, and notices (chronologically) published in the Federal Register relating to 21 CFR Part 556 after this date.

  • 2015-10-13; vol. 80 # 197 - Tuesday, October 13, 2015
    1. 80 FR 61293 - New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of a New Animal Drug Application; Change of Sponsor; Change of Sponsor's Address
      GPO FDSys XML | Text
      DEPARTMENT OF HEALTH AND HUMAN SERVICES, Food and Drug Administration
      Final rule; technical amendment.
      This rule is effective October 13, 2015, except for the amendment to 21 CFR 558.460, which is effective October 23, 2015.
      21 CFR Parts 510, 520, 522, 524, 556, and 558