105 CMR 720.200 - Appendix A | State Regulations | US Law

1. Look up the drug product by the brand name in the index or by generic name in the "Approved Drug Products with Therapeutic Equivalence Evaluations" ("Orange Book"). The drug products are arranged alphabetically.

2. Compare the dosage form and strength of the drug product prescribed with the dosage form and strength of the same drug product in the "Orange Book".

3. If the same drug product, dosage form and strength has been assigned an "A" rating by FDA and is not listed on the Exception List contained within 105 CMR 720.050, the drug product is interchangeable.

4. If the drug product is not listed in the "Orange Book", refer to 105 CMR 720.050(b), the Massachusetts Additional List of Interchangeable Drugs (Additional List).

5. Look up the drug product by the generic name inthe Additional List. The drug products are arranged alphabetically.

6. Compare the dosage form and strength of the drug product prescribed with the dosage form and strength of the same drug product listed on the Additional List.

7. If the same drug product, dosage form and strength are listed, the drug product is interchangeable.

Copies of the "Approved Drug Products with Therapeutic Equivalence Evaluations" and its supplements ("Orange Book") are available from the:

U.S. Food and Drug Administration

Department of Health and Human Services

Government Printing Office

Washington, D.C. 20402-9371

OPC 6768

(202) 783-3238

and www.fda.gov/cder/drug

Copies of the USP DI (third volume of USP DI is the "Orange Book") are available from:

The United States Pharmacopeial Convention, Inc.,

12601 Twinbrook Parkway

Rockville, MD 20852

(301) 881-0666

Copies of the Massachusetts Additional List of Interchangeable Drug Products (document number 105 CMR 720.000) are available from:

The State House Bookstore Room 116

Boston, MA 02133

(617) 727-2834

and www.magnet.state.ma.us/dph/dcp/Drug Formulary/Drug Interchange

TABLE OF CONTENTS

Foreword

Introduction

Drug Product Problem Reporting Instructions

Exception List

Format of the Additional List

NDA, ANDA, Applicant (name) Changes

Abbreviations

Massachusetts Additional List of Interchangeable Drugs (Alphabetical list of Official (Generic) Drug Names)

Parti al Proprietary Brand Cross-reference

FOREWORD

The Massachusetts List of Interchangeable Drugs, is prepared by the Drug Formulary Commission (DFC) and the Department of Public Health. The DFC is comprised of nine men and women appointed by the Governor for the express purpose of developing a list of those drug products that are safely interchangeable -- that is, equivalent to each other in all significant respects. The DFC was established by M.G.L. c. 17, § 13. This law was enacted with the intent of saving money for consumers ofprescription drugs, since drug products that are marketed under trademark or proprietary names are often available in the generic forms from competing manufacturers at substantially lower prices. M.G.L. c. 112, § 12D mandates prescription forms that allow practitioners to prescribe interchangeable drug products by simply signing the signature line. If a practitioner determines that a brand name drug product should be dispensed, he/she must sign the signature line and write the words "no substitution" in his/her own handwriting in the space provided below the signature line.

The regulations call for the automatic adoptionof "A"rated drugproducts listed in the "Approved Drug Products with Therapeutic Equivalence Evaluations" and its supplements (commonly referred to as the "Orange Book") as published by the U.S. Food and Drug Administration, Department of Healthand Human Services, plus a list of additional drug products, the Massachusetts Additional List of Interchangeable Drugs ("Additional List"), individually reviewed and approved by the DFC and the Department. The regulations provide the criteria upon which the drug products listed on the Additional List are approved for interchange. The regulations also provide the DFC and the Department with the authority to review any "A" rated drug product listed in the "Orange Book" or drug product approved for interchange on the Additional List and delete it from the list of interchangeable drug products if deemed appropriate. Drug products assigned an "A" rating by FDA which are deleted from the Massachusetts List are placed on the Exception List. Drug products listed on the Additional List which are subsequently deleted are removed from the Additional List.

Of the many factors considered by the Commission in determining which drugs to include on the List, equivalent safety and effectiveness are paramount. The Commission reviews evidence on bioequivalence and pharmaceutical equivalence and includes on the List only those drug products determined to be fully interchangeable and whose manufacturers are approved by the U.S. Food and Drug Administration. Practitioners may prescribe any drug that appears on the List with confidence that it is as safe and effective as its brand name counterpart.

The efforts of the Commission in the assessment and evaluation ofdata and the preparationofthe List are to be commended. The Department presents the Massachusetts List of Interchangeable Drugs with pride and with confidence that the List will greatly benefit consumers throughout the Commonwealth.

INTRODUCTION

INTERCHANGEABLE (GENERIC) DRUG LAW

In 1976 the Massachusetts Legislature passed an Act Further Regulating the Establishment of a Formulary of Interchangeable Drug Products (St. 1976, c. 470, § 13), commonly known as the Generic Drug Law. This law, enacted to promote and regulate the use of generic drugs, created the Drug Formulary Commission to develop a list of interchangeable drug products and also required the use of a standard prescription form to encourage practitioners to prescribe generic drugs.

PRESCRIPTION FORM

M.G.L. c. 112, § 12D mandates prescription forms with one signature line. Ifthe prescriber signs the prescription form and writes the words "no substitution" in his/her own handwriting in the space provided below the signature line, the pharmacist must fill the prescription exactly as indicated, with no interchange permitted. However, if the prescriber signs the prescription and does not write "no substitution" under his/her signature, the pharmacist is legally required to dispense a less expensive, equivalent interchangeable drug product listed in the Massachusetts List of Interchangeable Drugs if one is reasonably available.

MASSACHUSETTS LIST OF INTERCHANGEABLE DRUGS

The Massachusetts List of Interchangeable Drugs (MLID) consists of the "A" rated drug products listed in the "Approved Drug Products with Therapeutic Equivalence Evaluations" and its supplements as published by the U.S. Food and Drug Administration, Department of Health and Human Services ("Orange Book") and the Massachusetts Additional List of Interchangeable Drugs (Additional List). The Additional List is developed by the Drug Formulary Commission. The Commission determines drug products to be interchangeable only when they meet certain criteria:

(a) the drug product is available from more than one source, with the same active ingredient in the same dosage form and strength;

(b) its manufacturer is approved by the U.S. Food and Drug Administration (FDA); and

(c) when essential to therapeutic outcome, the manufacturer of the drug has documented clinical evidence of bioequivalence.

The Commission judges that all the drugs included on the MLID meet these standards and are bioequivalent, if essential, based on assessment and evaluation of the U.S. Pharmacopeia and its supplements, other state and hospital formularies, listings of the U.S. Department of Health and Human Services of the FDA, and on the expertise of its members.

The List does not include:

(a) drugs that are protected by patent rights or available from only one source;

(b) many controlled-release and enteric coated drug products since they may not consistently deliver the same quantities of their active ingredients;

(c) those drugs for which the Commission had any significant doubt about safe interchange between manufacturers; and

(d) any drug for which bioequivalence is considered essential but for which bioequivalence has not been demonstrated or an appropriate standard for bioequivalence has not been established.

Bioequivalence is determined to be necessary for a particular drug when bioinequivalence might result in therapeutic failure or hazard to the patient. Bioequivalent drug products do not show a significant difference in the rate and extent of absorption when administered at the same dosage under similar conditions. Drugs that are equivalent in the extent to which they are absorbed into a patient's body that differ in the rate of absorption may be therapeutically equivalent -- having the same medical effect -- either because the rate of absorption is not essential to the attainment of effective body concentrations of the drug, or because the difference in the rate is otherwise considered medically insignificant. Bioequivalence is a primary consideration for those drug products with a narrow therapeutic/toxic dosage range (when variation in the rate orextent of absorption could have a critical effect) where careful determination of the correct dosage and monitoring of the patient is essential to safe and effective use. To determine for which drugs bioequivalence is essential, the Commission relies on expert medical testimony, studies done by the pharmaceutical industry, the knowledge and expertise of the individual members of the Commission, and advice from the FDA.

All drug products manufactured by FDA approved firms are considered safe and effective for their intended use, even if the product has not been included in the MLID. A practitioner may begin a patient's therapy with a drug product from any manufacturer who has been approved by the FDA, even though interchange of the drug once the dosage has been calculated for the individual is not advised.

Several generic drug products are manufactured under the same new drug application (NDA) as the brand name drug products. According to section 1.6 of the Orange Book, drug products with the same NDA are therapeutically equivalent. Massachusetts regulations allow the interchange of these products. Distributors or repackagers of drug products manufactured under the same NDA as the brand name product are not identified in the Orange Book. Pharmacists who may not be able to determine if drug products are interchangeable should contact the manufacturers, distributors or repackagers. In addition the Department maintains an unofficial list of these products.

Information relative to the Interchangeable (Generic) Drug Law may be obtained from the Department of Public Health, Division of Food and Drugs, 305 South Street, Jamaica Plain, MA 02130, telephone number (617) 727-2670, and from the Boards of Registration in Medicine, Dentistry and Pharmacy.

DRUG PRODUCT PROBLEM REPORTING INSTRUCTIONS

Since 1971 the United States Pharmacopeia (USP), in cooperation with various professional associations and the Food and Drug Administration (FDA), has operated the Drug Product Problem Reporting Program. This program can be utilized by pharmacists, physicians, or consumers to report any product problems encountered when using drugs interchanged under the Massachusetts generic drug law. The program is product oriented, and patient identification not requested. Should you prefer to remain anonymous, so indicate to the USP and your name will be withheld from the manufacturer and the FDA. Your participation in reporting problems will help to ensure that the drug products prescribed and dispensed in Massachusetts are of continued high quality.

Reports should be sent to The United States Pharmacopeial Convention, Inc., 12601 Twinbrook Parkway, Rockville, MD 20852, (301) 881-0666. The USP is an impartial, non-governmental organization concerned with drug standards and quality control. After USP receives a report, copies are forwarded to the FDA and to the manufacturer of the product involved. Either the FDA or the manufacturer may act to investigate or correct problems.

EXCEPTION LIST

Orange Book "A" rated drug products not approved for interchange.

There are currently no products designated to be listed on the Exception List.

ADDITIONAL LIST

The Massachusetts Additional List of Interchangeable Drugs (Additional List) has been printed in a format designed to be concise and understandable. Interchangeable drugs are listed alphabetically according to their official (chemical or generic) names, and separate sections in each listing show dosage forms, strengths, FDA approved manufacturers, and categories.

DRUG

Drugs are listed in alphabetical order by their generic names and are printed in capital letters. Drug products containing more than one active ingredient (for example, CODEINE PHOSPHATE, GUAIFENESIN) are listed in the conventional order of ingredients.

Only drug products grouped under single headings are to be interchanged.

DOSAGE FORM

Under the generic names are listed the various multisource dosage forms in which a drug product is available. Abbreviations used for dosage forms and approved manufacturers are found in the front of the Additional List.

Only identical dosage forms and strengths of identical drugs are to be interchanged.

STRENGTH

The approved strengths of the drug products are listed under the heading "Strength(s)." The "strengths" must be read along with the "dosage forms" since any strength shown is available only for the dosage form directly to its left. Dosage strength is in metric units that are sometimes rounded off from apothecary measures, which may introduce slight variations in the strength of certain products. Single ingredient drug product strengths are separated by commas. Combination drug products have a slash separating the strengths of the individual ingredients. If more than one strength of a single component of a combination drug product is approved, they will be separated by commas. For example, the strength of a tablet of aspirin with codeine phosphate is "325mg / 15mg, 30mg, 60mg" which means that the combination is available with 325 milligrams of aspirin and 15, 30, or 60 milligrams of codeine phosphate. Drug products with three or more components have their active ingredients listed individually in parentheses and have slashes separating the strengths of the individual ingredients.

MANUFACTURERS

Next to the heading "Manufacturers" are all approved manufacturers for the drug product in that group, listed by three letter abbreviations in capital letters. (See list of manufacturer abbreviations in front of the Additional List.) Listed manufacturers have met all legal requirements, including compliance with the FDA Good Manufacturing Practices for the production of the drug product indicated. Approved manufacturers hold current new drug applications (NDAs) or abbreviated new drug applications (ANDAs) when required by law.

NDA, ANDA APPLICANT (NAME) CHANGES

Because it is not practical to identify in the Massachusetts Additional List of Interchangeable Drugs (Additional List) each and every product involved when an applicant transfers its entire line of approved drug products to another applicant, or when an applicant changes its name, these transfers and name changes are identified in this section. In addition, the new manufacturers are listed in parenthesis beside the original manufacturer under the Manufacturers' Abbreviations section of the Additional List. Where only partial approved product lines are transferred between applicants, each approved product involved will appear with the manufacturer name change in the Additional List amendment.

Previously listed name changes have been incorporated into the revised Manufacturers' Abbreviations section.

ABBREVIATIONS

The following abbreviations are used in the Massachusetts List of Interchangeable Drugs.

DOSAGE FORMS

aero	aerosol
amp	ampule
cap	capsule
conc	concentrate
e.c.	enteric-coated
elix	elixir
g	gram
Hbr	hydrobromide
HCl	hydrochloride
HC	hydrocortisone
inhl	inhalation
inhl liquid	inhalation liquid
inhl sol	inhalation solution
inj	injection
irr sol	irrigating solution
I.U.	international units
liq	liquid
lot	lotion
mcg	microgram
mEq	milliequivalents
mg	milligram
ml	milliliter
oint	ointment
ophth	ophthalmic
oral gran	oral granules for
reconstitution
oral powder	oral powder for
reconstitution
oral sol	oral solution
pow	powder
sol	solution
SR	sustained release
subl tab	sublingual tablet
supp	suppository
susp	suspension
syr	syrup
tab	tablet
top aero	topical aerosol
top swab	topical swab
U	units
vag	vaginal

MANUFACTURERS' ABBREVIATIONS

3MP	3M Pharmaceutical
AAA	Alpha Therapeutic
ABB	Abbott
ABI	Abic
ABL	Able Laboratories
ACI	ACIC Limited
ACP	Advanced Care Prod.
ADV	Advanced Remedies
AGV	Agvar Chemicals
AKO	Akorn
AKZ	Akzona Inc.
ALC	Alcon Labs
ALL	Allergan Pharmaceuticals
ALI	Alliance Pharmaceutical
ALP	Alpharma
APP	Alphapharm Party
ALT	Altana
ALZ	Alza Corp.
ALR	Alra Laboratories
AMA	Amaric
AMB	Ambix Labs
ACC	American Cyanamid Co.
AHP	American Home Products
ARL	American Regent Labs.
AME	Amersham
AMG	Amgen
AMI	Amide Pharmaceuticals
AMT	American Therapeutics
ANA	Anabolic
ANB	Anbex
ANC	Angus Chemical
ANE	Anesta
ANG	Angelini
APO	Apothecon
APK	Apothekernes
APP	American Pharmaceutical Partners
Inc
ARC	Arcola Labs.
APC	Arcum Pharmaceuticlal Corp.
ARP	Armenpharm
ARM	Armour Pharmaceuticals
ASC	Ascot Hospital Products
ASA	Asta
ASP	Astra Pharmaceuticals LP
ATH	Athena Neurosciences
BAK	Baker Norton
BAN	Banner Pharmacaps
BAP	Barlan Pharmacal
B/I	Boehringer Ingelheim
B/M	Boehringer Mannheim. Ther. Div
BAR	Barr Labs
BAS	Basel Pharmaceuticals
BAT	Bartor
B&L	Bausch & Lomb
BAY	Bayer Corp
BEA	Beach Prod.
B-D	Becton,Dickinson & Co.
BED	Bedford Laboratories
BEL	Bell
BDP	Beta Derm Pharmaceuticals
BER	Berlex
BFA	B.F. Asher
BHC	B.H. Chemicals
BID	Biodevelopment
BIO	Bio Technology General
BIV	Biovail
BLA	Blairex Laboratories
BLO	Block Drug Co.
BLU	Bluline
BRL	Blue Ridge Laboratories
BOC	Bock Pharmacal
BOW	Bowman Pharm.
BMS	Bristol Myers Squibb
BRC	Bracco Diagnostics
BRD	Bradley Pharm.
BRA	Braintree Laboratories
BRI	Bristol-Myers Prod.
BTG	BTG Pharmaceuticals
BVL	Ben-Venue Labs
BYR	Byron Chemical
C&M	C & M Pharmacal
CAD	Cadema Medical Products
CAG	Calgon Corp.
CDC	Carderm Capital
C-P	Chesebrough - Ponds
C-W	Cook - Waite
C/C	Chase Chemical
CSL	Chase Laboratories
C/P	Corvit Pharmaceuticals
CAL	Carlisle
CAM	Camall
CAR	Carnick Labs
CTW	CarterWallace
CEN	Century Pharmaceuticals
CBV	Cetus Ben Venue Therapeutics
CHA	Chamberlin Parenteral Corp.
CHE	Chelsea Laboratories
CHM	Chemed Corp.
CVO	Ciba Vision Ophthalmics
CIR	Circa Pharmaceuticals
CJD	Copanos, J.D.
CLA	Clay - Park
CLO	Clonmel Healthcare
CMB	C.M. Bundy
CMC	Consolidated Midland Corp.
C/T	Controlled Therapeutics
CMP	Carolina Medical Products
CNC	H.R. Cenci
COL	Colgate Palmolive
COM	Combe
CON	Connaught Laboratories
COO	Cooper Labs
COP	Copley Pharmaceutical
CPG	Consolidated Pharmacy Group
CRE	Creighton Products
CUM	Cumberland Swan
CUR	Curatex Pharmaceuticals
CTL	Central Pharmacal
D&G	Davis & Geck
D/L	DPT Laboratories
D-R	Del-Ray Laboratories Inc.
DAN	Danbury Pharmacal
DAR	Darby Group Companies
DEL	Dell
DEP	Deproco
DER	Dermik Laboratories
DES	Deseret Medical
DEY	Deylabs
DHL	DHL Laboratories
DIA	Dial Corp.
DIS	Dista
DMD	Duramed
DMG	D M Graham Laboratories
DOW	Dow Pharmaceutical
DPT	Dupont Pharmaceuticals
DPM	Dupont Merck
DUR	Dura Pharmaceuticals
DUN	Dunhall
DYN	Dynapharm
E/K	Eastman Kodak
EAT	Eaton Medical Corp.
ECR	ECR Pharmaceuticals
ELA	Elan Pharmaceuticals
ELL	Ellis Pharmaceuticals
EMP	EM Pharma
END	Endo
EON	Eon Laboratories
ENQ	Enquay Pharm
ENZ	Enzon
ESR	Elkins-Sinn/AH Robins
ERS	Ersana
ESI	ESI Lederle Generics
ESP	ESI Pharmacal
ETH	Ethicon Inc.
ETX	Ethex
ETK	Ethitek Pharmaceuticals
EVY	Everylife
EZC	E Z EM Co.
FAU	Faulding Pharm. Co.
FER	Ferndale
FRT	Ferrante
FRR	Ferring Labs
FIS	Fisons
FLE	Fleming & Co.
FOR	Forest
FOU	Fougera
FOY	Foy
FRE	Fresenius
G&W	G & W
GAL	Galderma
GEI	Geigy
GEC	Gencon
GED	Genderm
GET	Genentech
GEP	Genpharm
GEV	Geneva
GES	Gensia Sicor Pharmaceuticals Inc
GEZ	Genzyme
GIL	Gilbert Laboratories
GLD	Glades
GLW	GlaxoWellcome
GLE	Glenwood
GLO	Global Pharm.
G/P	Golden Pharms.
GOL	Goldine
GRE	Greenstone
GRI	Griffen,KW
G/L	Gruppo Lepetit
GUA	Guardian
GYM	GYMA Laboratories
GYN	Gynopharm
H-R	Holland-Rantos
HAL	Halsey Labs
HAM	Hamilton Pharmaceuticals
HAN	Hnford GC
HEA	Heather
HEN	Heran Pharmaceutical
HEX	Hexcel Chemical Products
HER	Hermal Pharmaceutical
HIC	Hickam
H/D	Hill Dermaceuticals
HIR	Hirsch Industries
HIT	Hi Tech Pharma
HTP	High Technology Pharmacal
HLC	Halocarbon
HCC	Hoechst Celanese Corp.
HMR	Hoechst Marion Roussell
HOE	Hoechst-Rousel
HOR	Horus Therapeutics
HOY	Hoyt
HUD	Hudson Pharmaceuticals
HUN	Huntington
HYB	Hybritec Inc.
HYG	Hygenics
HYR	Hyrex
IMM	Immunex
IMP	IMP Inc.
ICN	ICN Pharmaceuticals
IMS	International Medication
INP	Interpharm
INV	Invamed, Inc.
INW	Inwood Labs
ICC	Interchem Corp.
ILC	International Latex Corp.
ING	Ingram Pharmaceutical
INH	Inhalon
IOL	Iolab
IOM	Iomed
IPR	IPR Pharm
IVA	IVAX
J&J	Johnson & Johnson
JAC	Jacobus
JAN	Janssen Pharmaceuticals
JER	Jerome Stevens Labs
JRW	Johnson RW
JON	Jones Pharma Inc
KAL	Kalapharm
KBP	Kabi Pharmacia
KEE	Keene
KED	Kendall
KEN	Kenwood
KIN	King Pharmaceuticals
KIR	Kirkman Sales
KNO	Knoll
KPI	Key Pharmaceuticals
KVP	KV Pharmaceutical Co.
L/F	Labs Fournier
L/A	Laboratories Atral
LAF	Lafayette Pharms
LAN	Lannett
LED	Lederle
LEI	Leiras
LEK	Lek Ljubliana
LEM	Lemmon
LEO	Leo Pharms
LIF	Life Labs
LIL	Lilly
LIP	Liposome
LIQ	Liquipharm
LNK	LNK International
LOC	Loch Pharmaceuticals
LOR	Lorex
LOT	Lotus Biochemical
LPI	LPI Holding
LUI	Luitpold
LUS	Lek USA Inc.
LYN	LYNE Laboratories
M/P	Mallinckrodt Pharmaceutical.
MAY	Mayrand
MAT	Matrix Labs
MCG	Mcgaw
MCN	McNeil Consumer Products
MDP	MD Pharmaceuticals
MEA	Mead Johnson
MJN	Mead Johnson Nutritionals
M/R	Medco Research
MVA	Medeva
MEP	Medics Pharmaceuticals
MPI	Medi Physics, Inc.
MAG	Mepha AG
MER	Mericon
MET	Metronic
MGI	MGI Pharma
MID	Midway Medical
MIK	Mikart Laboratories
MIS	Mission Pharmacol
MJP	MJ Pharmaceuticals
MKL	Moore Kirk Labs
MLI	Marchar Laboratories
MLP	Miller Pharmacal
MLX	Milex
MMD	Marion Merrell Dow
MOR	Morton Grove
MCK	Merck & Co.
MSM	Marsam
MSL	Marshall Pharmacal
MTC	Martec
MOV	Mova
MUR	Muro
MUT	Mutual Pharmaceuticals
MYL	Mylan Pharmaceuticals
NEP	Nephron Pharmaceuticals Inc
NEU	Neutrogena
NOR	Norbrook Laboratories
N/W	Norton Waterford
N/N	Novo Nordisk
NEW	Newtron Pharmaceuticals
NHN	Norton HN
NOV	Novocol
NVP	Novopharm Ltd.
NUM	Numark
NYC	Nycomed
NYL	Nylos Trading
ORI	Organon, Inc.
OCL	Oclassen
OHM	OHM Laboratories
OMD	Ohmeda Pharmaceutical
OSA	On Site Azla
ODC	Ormont Drug & Chemical
OPC	Ortho Pharmaceuticals
OPT	Optopic Laboratories Corp.
ORG	Organics
OAP	Otsuka America Pharmaceutical
PAK	Pal-Pak
PAL	Palisades
P/D	Parke Davis
P/I	Plantex/Ikpharm
P/K	Purepac-Kalipharma
P/P	Parmed Pharmaceuticals
PAC	Paco Research
PAD	Paddock Labs
PHD	Pharmaderm
PAN	Panray
PAR	Par
PNL	Parnell
PER	Perrigo
PCE	Pharmachemie
PHC	Pharmics
PHK	Pharmakinetics Labs
PHM	Pharmeral
PHO	Phoenix Labs
PHS	Pharma Serve
PHT	Pharmaton
PFF	Pfeiffer
PFI	Pfizer
P/U	Pharmacia & Upjohn
P/A	Pharmaceutical Association
PIO	Pioneer Pharmaceutical Inc.
PPI	Physicians Products Inc.
PSA	Pharmaceutical Specialist Assoc
POH	Pohl Boskamp
POL	Polymedia
PGP	Prographarm
PRD	Professional Disposables
PRO	Proter Laboratory
PRI	Private Formulations
P&G	Proctor & Gamble
PRV	Pharmavite
PTK	Pharma-Tek
PUF	Purdue Frederick
PUR	Purepac
QUA	Quantum Pharmics Ltd.
QLT	QLT PhototherapeuticsInc.
RAN	Ranbaxy Pharmaceuticals
R/C	Reckitt & Colman
R&C	Reed & Carnrick
R/I	Research Industries
RXP	Rexar Pharmacal
RAC	Rachelle Labs
REN	Ren-Pharm Internatl. Ltd.
RHP	Rhone - Poulenc
RPR	Rhone-Poulenc Rorer
RAH	Robins, A.H.
REX	Rexall/Sundown
RIC	Richlyn Labs
ROC	Roche Labs.
RPF	Roerig/Pfizer
ROA	Roaco
RBP	Roberts Pharmaceutical
ROR	Rorer
ROS	Ross Labs
ROX	Roxane Labs
ROY	Royce Laboratories
RPC	Rosemont Pharmaceutical Corp
RUG	Rugby Labs
S-M	Spencer-Mead
S/W	Sanofi Winthrop
S/L	Schmid Laboratories
SAK	Sankyo
SAV	Savage Labs/Altana
SAN	Sandoz
SCE	Scherer, R.P.
SPI	Schein Pharmaceutical, Inc.
SCH	Schering Corporation
S/P	Schering/Plough
SWZ	Schwarz Pharma
SZG	SchwarzGMBH
SCI	ScinoPharm International
SCS	SCS Pharmaceuticals
SEA	Searle
SER	Serono Laboratories
SEQ	Sequus Pharmaceuticals
SHM	Sherwood Medical
SHI	Shionogi USA
SID	Sidmak Laboratories
SIG	Sigma Tau
SIX	Silarx
SKB	Smith, Kline Beecham
SBH	Sola Barnes Hind
SOL	Solopak Laboratories
SLV	Solvay
SOM	Somerset
SBM	Sorin Biomedics
SDP	Sperti Drug Products
STI	Steifel
STL	Stanlabs Pharmaceutical Co.
STR	Star Pharmaceuticals
STS	Steris Laboratories
STZ	Storz Ophthalmics
SUP	Superpharm
SPP	Suppositoria
SUR	Survival Technology
SYN	Syntex
SYO	Syosset Labs
TAB	Tablicaps
TAG	Tag Pharmaceuticals
TAK	Takeda
TAP	Tap Holdings
TAR	Taro Pharmaceutical
TAY	Taylor Pharmaceuticals
TEC	Technilab
THE	Theratech
THK	Therakos
THA	Thames Phamacol Co. Inc.
TIC	Tican Pharmaceuticals
TOP	Topiderm
T/L	Torch Laboratories
TOR	Torigian Lab
UDL	UDL Laboratories
UMD	Unimed
UPJ	Upjohn
USL	Upsher-Smith Labs
VAL	Vale Chemical
VAN	Vangard
VES	Vestal
VIC	Vicks Pharmacy Products
VIN	Vintage
VIR	Viratek
VIS	Vistakon, Inc.
VIV	Vivan Pharmacal
W-A	Wyeth Ayerst
W-C	Warner-Chilcott
WAW	Warner Wellcome
WRR	Warrick Pharm
WEP	WE Pharmaceuticals
WEN	Wendt Laboratories
WPP	West Point Pharma
WES	Westwood Squibb Pharmaceuticals
W-W	West-Ward
W/L	Wharton Labs
WBY	Whitby
WWT	Whiteworth Towne
WAL	Wallace Labs
WAR	Warner-Lambert
WAT	Watson Laboratories
WOC	Wockhardt
XTT	Xttrium Laboratories
YAM	Yamanouchi
YOS	Yoshitomi Laboratories
ZCA	Zeneca
ZGP	Zenith Goldline Pharmaceuticals

MASSACHUSETTS ADDITIONAL LIST OF INTERCHANGEABLE DRUGS

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PARTIAL PROPRIETARY BRAND CROSS-REFERENCE

Generically equivalent drug products in the same strength and dosage form listed in the Additional List are interchangeable if their respective manufacturers are listed for that product. This partial crossreference section does not attempt to list all brand names which are approvedforinterchange. Formost products only one, usually the innovator or most commonly prescribed brand, is listed below for quick reference purposes.

See page 4105 for precise instructions for determining the interchangeability of drug products.

BRAND SEE

(ATROPINE SULFATE, HYOSCINE HBr, HYOSCYAMINE HBr, PHENOBARBITAL)

(THEOPHYLLINE, POTASSIUM IODIDE, ALCOHOL)

ACTIFED ............................................................TRIPROLIDINE HCl, PSEUDOEPHEDRINE HCl

ANDROID..............................................................................METHYLTESTOSTERONE

ANTABUSE DISULFIRAM

AQUAMEPHYTON............................................................................. PHYTONADIONE

AURALGAN......................................................................... BENZOCAINE, ANTIPYRINE

AZO-GANTANOL.................................................... SULFAMETHOXAZOLE, PHENAZOPYRIDINE

AZO-GANTRISIN .......................................................SULFISOXAZOLE PHENAZOPYRIDINE HCl

AZULFADINE ................................................................................. SULFASALAZINE

BENADRYL ............................................................................DIPHENHYDRAMINE HCl

CYANOCOBALAMIN

BICILLIN............................................................................ PENICILLIN G BENZATHINE

BRETHINE ............................................................................. TERBUTALINE SULFATE

CHLOR-TRIMETON............................................................. CHLORPHENIRAMINE MALEATE

COL-BENEMID .................................................................... PROBENECID W/ COLCHICINE

CYCLANDELATE

DECADRON ................................................................................. DEXAMETHASONE

DESQUAM .................................................................................BENZOYL PEROXIDE

DIMETANE DX................................ BROMPHENIRAMINE, DEXTROMETHORPHAN, PSEUDOEPHEDRINE

DIUPRESS......................................................................CHLOROTHIAZIDE W/ RESERPINE

DONNATAL................................................................... ATROPINE SULFATE COMPOUND

DRAMAMINE ...............................................................................DIMENHYDRINATE

DRIXORAL.................................................................................. (product reformulated)

ECONOPRED ......................................................................... PREDNISOLONE ACETATE

ELIXOPHYLLINE KI ......................................................... THEOPHYLLINE, POTASSIUM IODIDE

EMPIRIN W/ CODEINE .........................................................ASPIRIN W/ CODEINE PHOSPHATE

ESTINYL .................................................................................. ETHINYL ESTRADIOL

EXNA. ........................................................................................ BENZTHIAZIDE

FEDAHIST............................................. PSEUDOEPHEDRINE HCl, CHLORPHENIRAMINE MALEATE

GLAUCON ....................................................................................EPINEPHRINE HCl

GRANULEX ............................................................... TRYPSIN, BALSAM PERU, CASTOR OIL

HALOTESTIN .............................................................................FLUOX\YMESTERONE

HYCOMINE..........................................HYDROCODONE BITARTRATE W/ PHENYLPROPANOLAMINE

HYDROPRES ........................................................... HYDROCHLOROTHIAZIDE W/ RESERPINE

ISOPTO CARPINE ............................................................................. PILOCARPINE HCl

ISORDIL TEMBID....................................................................... ISOSORBIDE DINITRATE

ISUPREL .................................................................................. ISOPROTERENOL HCl

KAON. ............................................................................... POTASSIUM GLUCONATE

KENALOG ....................................................................... TRIAMCINOLONE DIACETATE

LARODOPA .........................................................................................LEVODOPA

LEVSIN ............................................................................. L-HYOSCYAMINE SULFATE

LIBRAX........................................................... CHLORDIAZEPOXIDE W/CLIDINIUM BROMIDE

MANDELAMINE ..................................................................METHENAMINE MANDELATE

MEBARAL ................................................................................... MEPHOBARBITAL

MENEST ...............................................................................ESTROGENS, ESTERIFIED

METALONE T.B.A ...................................................................PREDNISOLONE TEBUTATE

MICRONASE ....................................................................................... GLYBURIDE

MAGNESIUM SALICYLATE

NEO-SYNEPHRINE ......................................................................... PHENYLEPHRINE HCl

CHLORAL HYDRATE

PAMELOR .................................................................................NORTRIPTYLINE HCl

PHENERGAN PLAIN ....................................................................... PROMETHAZINE HCl

PONTOCAINE .................................................................................TETRACAINE HCl

PROSED.................................METHENAMINE COMBINATION (METHENAMINE, PHENYLSALICYLATE,

ATROPINE SULFATE, HYOSCYAMINE, BENZOIC ACID METHYLENE BLUE)

PROSTIGMINE .................................................................NEOSTIGMINE METHYLSULFATE

PYRIDIUM ..............................................................................PHENAZOPYRIDINE HCl

QUINAMM ..................................................................................QUININE SULFATE

SALUTENSIN ............................................................... HYDROFLUMETHIAZIDE, RESERPINE

SANOREX.......................................................................................... MAZINDOL

SERAPES.............................................. HYDRALAZINE HCl, HYDROCHLOROTHIAZIDE, RESERPINE

SLO-PHYLLIN GG ................................................................. THEOPHYLLINE, GUAIFENESIN

SLO-PHYLLIN ....................................................... THEOPHYLLINE (NON-SUSTAINED RELEASE)

SSKI. ...................................................................................... POTASSIUM IODIDE

SUDAFED ...............................................................................PSEUDOEPHEDRINE HCl

SYNTHROID .........................................................................LEVOTHYROXINE SODIUM

TENUATE................................................................................ DIETHYLPROPION HCl

TESTOSTERONE

TUINAL ......................................................AMOBARBITAL SODIUM, SECOBARBITAL SODIUM

VASODILAN ..................................................................................... ISOXSUPRINE

105 CMR 720.200 - Appendix A

Notes