(1) Definitions.
"Absolute filter" is one capable of retaining 99.97 percent of
a monodisperse aerosol of 0.3 µm particles.
For the purposes of OAR
437-002-0391, "carcinogen" is
defined as the substances regulated by
29 CFR
1910.1003,
1910.1004,
1910.1006,
1910.1007,
1910.1008,
1910.1009,
1910.1010,
1910.1011,
1910.1012,
1910.1013,
1910.1014,
1910.1015,
1910.1016 and OAR
437-002-0364.
(2) Laboratory activities. The requirements
of this section shall apply to research and quality control activities
involving the use of a carcinogen.
(a)
Mechanical pipetting aids shall be used for all pipetting procedures.
(b) Experiments, procedures and
equipment which could produce aerosols shall be confined to laboratory-type
hoods or glove boxes.
(c) Surfaces
on which a carcinogen is handled shall be protected from contamination.
(d) Contaminated wastes and animal
carcasses shall be collected in impervious containers which are closed and
decontaminated prior to removal from the work area. Such wastes and carcasses
shall be incinerated in such a manner that no carcinogenic products are
released.
(e) All other forms of a
carcinogen shall be inactivated prior to disposal.
(f) Laboratory vacuum systems shall be
protected with disposable absolute filters. Exhaust systems containing such
filters shall be provided with suitable ports or openings to enable
determination of whether the filter in its operating location, does meet the
efficiency requirements defined in OAR
437-002-0391(1).
Determination of filter efficiency shall be by measurement, with a forward
light scattering photometer, of passage of a polydisperse dioctyl phthalate
aerosol.
(g) Employees engaged in
animal support activities shall be:
(A)
Provided with, and required to wear, a complete protective clothing change,
clean each day, including coveralls or pants and shirt, foot covers, head
covers, gloves, and appropriate respiratory protective equipment or devices;
and
(B) Required to remove and
leave protective clothing and equipment at the point of exit prior to each exit
from a regulated area and at the last exit of the day, to place used clothing
and equipment in impervious containers at the point of exit for purposes of
decontamination or disposal. The contents of such impervious containers must
display the following warning:
DANGER
CONTAMINATED
MAY CAUSE CANCER
(C) Required to wash hands, forearms, face
and neck upon each exit from the regulated area close to the point of exit, and
before engaging in other activities; and
(D) Required to shower after the last exit of
the day.
(h) Employees,
other than those engaged only in animal support activities, each day shall be:
(A) Provided with and required to wear a
clean change of appropriate laboratory clothing, such as a solid front gown,
surgical scrub suit, or full buttoned laboratory coat.
(B) Required to remove and leave protective
clothing and equipment at the point of exit prior to each exit from a regulated
area and at the last exit of the day, to place used clothing and equipment in
impervious containers at the point of exit for purposes of decontamination or
disposal. The contents of such impervious containers must display the following
warning:
DANGER
CONTAMINATED
MAY CAUSE CANCER
(C) Required to wash hands, forearms, face
and neck upon each exit from the regulated area close to the point of exit, and
before engaging in other activities.
(i) Air pressure in laboratory areas and
animal rooms where a carcinogen is handled and bio- assay studies are performed
shall be negative in relation to the pressure in surrounding areas. Exhaust air
shall not be discharged to regulated areas, non-regulated areas or the external
environment unless decontaminated.
(j) There shall be no connection between
regulated areas and any other areas through the ventilation system.
(k) A current inventory of carcinogens shall
be maintained.
(l) Ventilated
apparatus such as laboratory type hoods, shall be tested at least semi-annually
or immediately after ventilation modification or maintenance operations, by
personnel fully qualified to certify correct containment and operation.